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BPC-157520·Semaglutide (GLP-1 Agonist)470·Rapamycin (Sirolimus)450·Nicotinamide Mononucleotide (NMN)410·Metformin380·Creatine Monohydrate340·Ashwagandha (KSM-66)290·Nicotinamide Riboside (NR)280·Vitamin D3260·Time-Restricted Eating (Intermittent Fasting)250·Cold Exposure (Cold Plunge/Shower)240·Omega-3 Fatty Acids (EPA/DHA)230·Sauna Use (Finnish-style)220·NAD+ IV Infusion210·Stem Cell Therapy200·Berberine190·Epithalon (Epitalon)180·Fisetin160·BPC-157520·Semaglutide (GLP-1 Agonist)470·Rapamycin (Sirolimus)450·Nicotinamide Mononucleotide (NMN)410·Metformin380·Creatine Monohydrate340·Ashwagandha (KSM-66)290·Nicotinamide Riboside (NR)280·Vitamin D3260·Time-Restricted Eating (Intermittent Fasting)250·Cold Exposure (Cold Plunge/Shower)240·Omega-3 Fatty Acids (EPA/DHA)230·Sauna Use (Finnish-style)220·NAD+ IV Infusion210·Stem Cell Therapy200·Berberine190·Epithalon (Epitalon)180·Fisetin160·

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Protocol Deep-Dive

Senolytic Protocol

by Mayo Clinic / Kirkland Lab

Intermittent senolytic cycles targeting clearance of senescent cells – the 'zombie cells' that accumulate with age and drive inflammation. Based on published clinical trial protocols.

4

Interventions

C+

Avg. Evidence

$15190–$25920

/month (stack)

Varies

Practitioner Est.

Intervention Stack

Supplement(2)

Fisetin

A flavonoid compound studied for its potential senolytic properties and cognitive benefits.

Quercetin

Flavonoid antioxidant studied for anti-inflammatory and senolytic properties in aging research

Pharmaceutical(2)

Dasatinib + Quercetin (Senolytic)

Research indicates this combination therapy may selectively eliminate senescent cells to slow aging processes.

Navitoclax (ABT-263)

Experimental BCL-2/BCL-xL inhibitor investigated as a senolytic drug to eliminate senescent cells

$15.0k–$25.0k/mo

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