Fisetin

**Fisetin is a naturally occurring flavonoid found in strawberries, apples, and other fruits that has gained attention for its potential anti-aging properties.** Research indicates that fisetin may act as a senolytic compound, meaning it could help eliminate senescent (aged and dysfunctional) cells that accumulate with age and contribute to inflammation and tissue dysfunction. Preliminary studies suggest doses of 20mg/kg body weight taken intermittently may be most effective for senolytic benefits.

**Current human research on fisetin remains limited but promising.** A small clinical trial in older adults showed potential benefits for reducing inflammatory markers, while another study in individuals with mild cognitive impairment suggested possible cognitive improvements. Most research has been conducted in laboratory and animal models, where fisetin demonstrated impressive longevity and healthspan benefits. The compound appears to be well-tolerated with minimal side effects reported in human studies.

**As a dietary supplement, fisetin is widely available and generally considered safe for most adults.** However, the optimal dosing regimen remains unclear, with some researchers suggesting intermittent high-dose protocols rather than daily supplementation. Given the early stage of human research, individuals considering fisetin should be aware that its long-term effects and interactions are not fully understood, though preclinical data continues to support its potential as an anti-aging intervention.