Molecular Targets
Interactive AlphaFold 3D structures of the key longevity proteins. Explore how interventions like rapamycin, metformin, and caloric restriction act at the molecular level – and which proteins they target.
mTOR
Mechanistic Target of Rapamycin · Serine/threonine kinase
SIRT1
NAD⁺-Dependent Deacetylase · Class III histone deacetylase
Klotho
Anti-Aging Hormone · Type I transmembrane protein
p53
Tumor Suppressor · Master Guardian of the Genome
AMPK α1
AMP-Activated Protein Kinase · Energy Sensor
FOXO3
Forkhead Transcription Factor · Longevity-Associated Gene
About these structures
All 3D protein structures are generated by AlphaFold 2, developed by Google DeepMind and EMBL-EBI. Structures are color-coded by prediction confidence (pLDDT score). Blue indicates very high confidence; orange indicates flexible or disordered regions. Structure data is provided under CC BY 4.0. alphafold.ebi.ac.uk