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L-Theanine

Amino acid from tea that research indicates may promote relaxation and cognitive performance without sedation.

Human Trials

18

1,247 participants

Risk Level

Low Risk

Monthly Cost

$8$25 /month

Based on 100-200mg daily dosing

Quick Facts

Category
Supplement
Research Field
Supplements
Evidence Grade
B+ – Good
Risk Level
Low
Monthly Cost
$8 – $25
Human Trials
18

Typical Dose

100–200 mg

Range

50–400 mg

Timingwith caffeine (2:1 theanine:caffeine ratio) or before bed for relaxation
Formcapsule or powder
NotesSynergistic with caffeine – reduces jitteriness without blunting alertness. Also effective as standalone sleep aid at 200–400 mg.

For informational purposes only – not medical advice. See disclaimer

Research Velocity

+21%
47 publications in the last 12 months · steady increase in publications

Mechanism of Action

L-theanine crosses the blood-brain barrier and increases alpha brain wave activity, which is associated with relaxed alertness. It modulates neurotransmitter levels including GABA, dopamine, and serotonin, while also blocking glutamate receptors. Research suggests it may reduce cortisol levels and promote a calm but focused mental state without causing drowsiness.

Overview

L-theanine is an amino acid naturally found in tea leaves, particularly green tea, that research indicates may promote relaxation without sedation. Studies suggest it can reduce stress markers including cortisol and blood pressure while enhancing alpha brain wave activity associated with calm alertness. Multiple human trials have demonstrated its potential to reduce anxiety and improve cognitive performance, particularly when combined with caffeine.

Research indicates L-theanine may be particularly beneficial for managing stress-related cognitive impairment and promoting focused relaxation. Clinical studies suggest typical effective doses range from 100-200mg daily, with effects typically observed within 30-60 minutes of consumption. The compound appears to have excellent safety profile with minimal reported side effects in healthy adults.

While naturally occurring in tea, therapeutic doses typically require supplementation as a cup of green tea contains only 5-8mg of L-theanine. Studies suggest it may be especially useful for individuals seeking cognitive enhancement without stimulant-related side effects, or those looking to moderate caffeine's anxiety-inducing properties while maintaining its cognitive benefits.

Known Interactions

  • May enhance effects of blood pressure medications
  • Can potentiate sedative effects of CNS depressants
  • May interact synergistically with caffeine for cognitive benefits

Legal Status by Country

📍

Your country (United States)

OTC
✈️

Available without prescription in:

Australia, Brazil, Canada, China, Colombia, Germany, India, Israel, Japan, Mexico, Netherlands, Panama, Russia, South Korea, Switzerland, Thailand, Turkey, UAE, United Kingdom, United States

Australia
OTC
✈️Brazil
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Canada
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China
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✈️Colombia
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Germany
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✈️India
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✈️Israel
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Japan
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✈️Mexico
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Netherlands
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✈️Panama
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Russia
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✈️South Korea
OTC
Switzerland
OTC
✈️Thailand
OTC
✈️Turkey
OTC
✈️UAE
OTC
United Kingdom
OTC
📍United States
OTC

📍 = your selected country · ✈️ = medical tourism destination · Always verify current local regulations before travel.

Last verified: 2026-03-16